Hypoalbuminaemia after Moxidectin (ProHeart 6) in dogs

303 reports to the FDA describe hypoalbuminaemia in dogs given Moxidectin. That is 0.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

303Reports

41%Marked serious

5.9%Recovered

42%Died or euthanised

2 daysTypical onset

How soon it started

Same day

55 37%

1–2 days

23 16%

3–7 days

22 15%

1–4 weeks

23 16%

Over a month

24 16%

How the animals did

Recovered

18 5.9%

Still unwell when reported

88 29%

Died

91 30%

Euthanised

37 12%

Not known

69 23%

Problems reported at the same time

173 57%

155 51%

152 50%

148 49%

129 43%

126 42%

108 36%

100 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

130

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hypoalbuminaemia in dogs?: 303 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoalbuminaemia with similar medicines

Hypoalbuminaemia after Ivermectin + Pyrantel (Heartgard Plus) 144 reports · 0.1% of its reports
Hypoalbuminaemia after Milbemycin Oxime + Spinosad (Trifexis) 179 reports · 0.1% of its reports
Hypoalbuminaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 57 reports · 0.2% of its reports
Hypoalbuminaemia after Milbemycin Oxime (Interceptor) 66 reports · 0.2% of its reports
Hypoalbuminaemia after Selamectin (Revolution) 71 reports · 0.2% of its reports
Hypoalbuminaemia after Ivermectin (Heartgard) 54 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hypoalbuminaemia