Hypernatremia after Moxidectin (ProHeart 6) in dogs

27 reports to the FDA describe hypernatremia in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.

27Reports

37%Marked serious

3.7%Recovered

33%Died or euthanised

–Typical onset

How the animals did

Recovered

1 3.7%

Still unwell when reported

4 15%

Died

6 22%

Euthanised

3 11%

Not known

13 48%

Problems reported at the same time

20 74%

15 56%

15 56%

14 52%

12 44%

10 37%

9 33%

8 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hypernatremia in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypernatremia with similar medicines

Hypernatremia after Ivermectin + Pyrantel (Heartgard Plus) 30 reports · 0.0% of its reports
Hypernatremia after Milbemycin Oxime + Spinosad (Trifexis) 29 reports · 0.0% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hypernatremia