Bone and joint disorder after Moxidectin (ProHeart 6) in dogs
23 reports to the FDA describe bone and joint disorder in dogs given Moxidectin. That is 0.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin cause bone and joint disorder in dogs?
- 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Bone and joint disorder with similar medicines
- Bone and joint disorder after Ivermectin + Pyrantel (Heartgard Plus) 33 reports · 0.0% of its reports
- Bone and joint disorder after Milbemycin Oxime + Spinosad (Trifexis) 189 reports · 0.1% of its reports
- Bone and joint disorder after Milbemycin Oxime + Praziquantel (Interceptor Plus) 58 reports · 0.2% of its reports
- Bone and joint disorder after Milbemycin Oxime (Interceptor) 29 reports · 0.1% of its reports
- Bone and joint disorder after Ivermectin (Heartgard) 29 reports · 0.2% of its reports
All reported side effects of Moxidectin in dogs · Medicines most reported with bone and joint disorder