Anxiety after Moxidectin (ProHeart 6) in dogs

156 reports to the FDA describe anxiety in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

156Reports

44%Marked serious

38%Recovered

5.8%Died or euthanised

Same dayTypical onset

How soon it started

Same day

97 66%

1–2 days

19 13%

3–7 days

7 4.8%

1–4 weeks

4 2.7%

Over a month

19 13%

How the animals did

Recovered

59 38%

Recovered with lasting effects

1 0.6%

Still unwell when reported

69 44%

Died

5 3.2%

Euthanised

4 2.6%

Not known

18 12%

Problems reported at the same time

54 35%

47 30%

43 28%

40 26%

34 22%

Restlessness or agitation

31 20%

Tremors

27 17%

Lethargy

25 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause anxiety in dogs?: 156 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

Anxiety after Ivermectin + Pyrantel (Heartgard Plus) 382 reports · 0.3% of its reports
Anxiety after Milbemycin Oxime + Spinosad (Trifexis) 623 reports · 0.5% of its reports
Anxiety after Milbemycin Oxime + Praziquantel (Interceptor Plus) 194 reports · 0.6% of its reports
Anxiety after Milbemycin Oxime (Interceptor) 70 reports · 0.2% of its reports
Anxiety after Selamectin (Revolution) 54 reports · 0.2% of its reports
Anxiety after Ivermectin (Heartgard) 75 reports · 0.6% of its reports
Anxiety after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 30 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with anxiety