Abnormal posture after Moxidectin (ProHeart 6) in dogs

61 reports to the FDA describe abnormal posture in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

61Reports

54%Marked serious

20%Recovered

18%Died or euthanised

1 daysTypical onset

How soon it started

Same day

18 35%

1–2 days

11 22%

3–7 days

5 9.8%

1–4 weeks

12 24%

Over a month

5 9.8%

How the animals did

Recovered

12 20%

Still unwell when reported

28 46%

Died

4 6.6%

Euthanised

7 11%

Not known

10 16%

Problems reported at the same time

29 48%

23 38%

15 25%

14 23%

13 21%

11 18%

9 15%

9 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause abnormal posture in dogs?: 61 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal posture with similar medicines

Abnormal posture after Ivermectin + Pyrantel (Heartgard Plus) 139 reports · 0.1% of its reports
Abnormal posture after Milbemycin Oxime + Spinosad (Trifexis) 1,182 reports · 0.9% of its reports
Abnormal posture after Milbemycin Oxime + Praziquantel (Interceptor Plus) 32 reports · 0.1% of its reports
Abnormal posture after Milbemycin Oxime (Interceptor) 25 reports · 0.1% of its reports
Abnormal posture after Selamectin (Revolution) 31 reports · 0.1% of its reports
Abnormal posture after Ivermectin (Heartgard) 46 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with abnormal posture