Didn't work as expected after Mirtazapine (Mirataz) in dogs

The FDA has received 49 reports of didn't work as expected in dogs after Mirtazapine. That is 17% of all reports for this medicine, compared with 13% across reports for all dog medicines.

49Reports

67%Marked serious

6.1%Recovered

37%Died or euthanised

11 daysTypical onset

How soon it started

Same day

8 22%

1–2 days

4 11%

3–7 days

3 8.1%

1–4 weeks

8 22%

Over a month

14 38%

How the animals did

Recovered

2 4.1%

Recovered with lasting effects

1 2.0%

Still unwell when reported

13 27%

Died

5 10%

Euthanised

13 27%

Not known

15 31%

Problems reported at the same time

20 41%

18 37%

13 27%

12 24%

9 18%

9 18%

8 16%

8 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Mirtazapine stimulates appetite (cats: ointment applied to the ear).

Products with this ingredient include Mirataz. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Mirtazapine cause didn't work as expected in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Maropitant (Cerenia) 2,045 reports · 17% of its reports
Didn't work as expected after Capromorelin (Entyce) 357 reports · 24% of its reports

All reported side effects of Mirtazapine in dogs · Medicines most reported with didn't work as expected