Walking difficulty after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

113 reports to the FDA describe walking difficulty in dogs given Milbemycin Oxime + Praziquantel. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

113Reports

53%Marked serious

27%Recovered

15%Died or euthanised

6 daysTypical onset

How soon it started

Same day

34 40%

1–2 days

7 8.1%

3–7 days

5 5.8%

1–4 weeks

6 7.0%

Over a month

34 40%

How the animals did

Recovered

30 27%

Still unwell when reported

44 39%

Died

5 4.4%

Euthanised

12 11%

Not known

22 19%

Problems reported at the same time

36 32%

29 26%

27 24%

22 19%

22 19%

21 19%

20 18%

18 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause walking difficulty in dogs?: 113 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

Walking difficulty after Ivermectin + Pyrantel (Heartgard Plus) 281 reports · 0.2% of its reports
Walking difficulty after Milbemycin Oxime + Spinosad (Trifexis) 580 reports · 0.4% of its reports
Walking difficulty after Moxidectin (ProHeart 6) 147 reports · 0.3% of its reports
Walking difficulty after Milbemycin Oxime (Interceptor) 34 reports · 0.1% of its reports
Walking difficulty after Selamectin (Revolution) 51 reports · 0.2% of its reports
Walking difficulty after Ivermectin (Heartgard) 70 reports · 0.6% of its reports
Walking difficulty after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 24 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with walking difficulty