Pyoderma after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

38 reports to the FDA describe pyoderma in dogs given Milbemycin Oxime + Praziquantel. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

38Reports

32%Marked serious

7.9%Recovered

0.0%Died or euthanised

44 daysTypical onset

How soon it started

Same day

3 13%

1–2 days

0 0.0%

3–7 days

2 8.7%

1–4 weeks

4 17%

Over a month

14 61%

How the animals did

Recovered

2 5.3%

Recovered with lasting effects

1 2.6%

Still unwell when reported

16 42%

Not known

19 50%

Problems reported at the same time

Itching

10 26%

Didn't prevent heartworm

10 26%

Vomiting

7 18%

Didn't work as expected

7 18%

6 16%

6 16%

6 16%

5 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause pyoderma in dogs?: 38 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 44 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pyoderma with similar medicines

Pyoderma after Ivermectin + Pyrantel (Heartgard Plus) 61 reports · 0.0% of its reports
Pyoderma after Milbemycin Oxime + Spinosad (Trifexis) 166 reports · 0.1% of its reports
Pyoderma after Moxidectin (ProHeart 6) 67 reports · 0.1% of its reports
Pyoderma after Milbemycin Oxime (Interceptor) 28 reports · 0.1% of its reports
Pyoderma after Selamectin (Revolution) 101 reports · 0.3% of its reports
Pyoderma after Ivermectin (Heartgard) 28 reports · 0.2% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with pyoderma