Drinking a lot after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

83 reports to the FDA describe drinking a lot in dogs given Milbemycin Oxime + Praziquantel. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

83Reports

23%Marked serious

22%Recovered

12%Died or euthanised

2 daysTypical onset

How soon it started

Same day

20 36%

1–2 days

8 15%

3–7 days

1 1.8%

1–4 weeks

5 9.1%

Over a month

21 38%

How the animals did

Recovered

18 22%

Still unwell when reported

30 36%

Died

5 6.0%

Euthanised

5 6.0%

Not known

25 30%

Problems reported at the same time

36 43%

30 36%

27 33%

18 22%

15 18%

14 17%

11 13%

10 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause drinking a lot in dogs?: 83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drinking a lot with similar medicines

Drinking a lot after Ivermectin + Pyrantel (Heartgard Plus) 118 reports · 0.1% of its reports
Drinking a lot after Milbemycin Oxime + Spinosad (Trifexis) 229 reports · 0.2% of its reports
Drinking a lot after Moxidectin (ProHeart 6) 37 reports · 0.1% of its reports
Drinking a lot after Ivermectin (Heartgard) 35 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with drinking a lot