Pulmonary disorder after Melarsomine (Immiticide) in dogs

73 reports to the FDA describe pulmonary disorder in dogs given Melarsomine. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

73Reports
82%Marked serious
14%Recovered
21%Died or euthanised
14 daysTypical onset
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How soon it started

Same day
14 22%
1–2 days
5 7.9%
3–7 days
8 13%
1–4 weeks
22 35%
Over a month
14 22%

How the animals did

Recovered
10 14%
Still unwell when reported
28 38%
Died
8 11%
Euthanised
7 9.6%
Not known
20 27%

Problems reported at the same time

Abnormal radiograph finding
45 62%
Breathing problems
35 48%
Cough
23 32%
Lethargy
22 30%
Vomiting
19 26%
Loss of appetite
16 22%
Death
15 21%
Liver problems
13 18%

Age of the animals

Under 1 year
0
1–3 years
25
4–7 years
34
8–11 years
11
12+ years
1

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause pulmonary disorder in dogs?
73 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 14 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Melarsomine in dogs · Medicines most reported with pulmonary disorder