Prolonged activated partial thrombin time (aptt) after Melarsomine (Immiticide) in dogs

21 reports to the FDA describe prolonged activated partial thrombin time (aptt) in dogs given Melarsomine. That is 0.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports
86%Marked serious
9.5%Recovered
19%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
3 14%
1–2 days
2 9.5%
3–7 days
8 38%
1–4 weeks
3 14%
Over a month
5 24%

How the animals did

Recovered
2 9.5%
Still unwell when reported
10 48%
Died
3 14%
Euthanised
1 4.8%
Not known
5 24%

Problems reported at the same time

Prolonged one stage prothrombin time (ospt)
5 24%

Age of the animals

Under 1 year
0
1–3 years
16
4–7 years
3
8–11 years
1
12+ years
0

About this medicine

Melarsomine treats adult heartworm infection (a series of injections given by a vet).

Products with this ingredient include Immiticide, Diroban. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Melarsomine cause prolonged activated partial thrombin time (aptt) in dogs?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Prolonged activated partial thrombin time (aptt) with similar medicines

All reported side effects of Melarsomine in dogs · Medicines most reported with prolonged activated partial thrombin time (aptt)