Walking difficulty after Lotilaner (Credelio) in dogs

73 reports to the FDA describe walking difficulty in dogs given Lotilaner. That is 0.7% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

73Reports
53%Marked serious
27%Recovered
14%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
20 33%
1–2 days
13 22%
3–7 days
5 8.3%
1–4 weeks
3 5.0%
Over a month
19 32%

How the animals did

Recovered
19 26%
Recovered with lasting effects
1 1.4%
Still unwell when reported
27 37%
Euthanised
10 14%
Not known
16 22%

Problems reported at the same time

Age of the animals

Under 1 year
15
1–3 years
11
4–7 years
20
8–11 years
13
12+ years
14

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause walking difficulty in dogs?
73 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

All reported side effects of Lotilaner in dogs · Medicines most reported with walking difficulty