Unpalatable after Lotilaner (Credelio) in dogs

The FDA has received 140 reports of unpalatable in dogs after Lotilaner. That is 1.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

140Reports

6.4%Marked serious

44%Recovered

2.1%Died or euthanised

1 daysTypical onset

How soon it started

Same day

56 48%

1–2 days

8 6.9%

3–7 days

5 4.3%

1–4 weeks

12 10%

Over a month

35 30%

How the animals did

Recovered

62 44%

Still unwell when reported

23 16%

Euthanised

3 2.1%

Not known

52 37%

Problems reported at the same time

52 37%

26 19%

20 14%

13 9.3%

13 9.3%

Product defect, product difficult to use/handle

12 8.6%

Didn't stop ticks

11 7.9%

Loss of appetite

11 7.9%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause unpalatable in dogs?: 140 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unpalatable with similar medicines

Unpalatable after Fluralaner (Bravecto) 407 reports · 0.6% of its reports
Unpalatable after Afoxolaner (NexGard) 51 reports · 0.1% of its reports
Unpalatable after Sarolaner (Simparica) 21 reports · 0.1% of its reports
Unpalatable after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports
Unpalatable after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 132 reports · 4.3% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with unpalatable