Unpalatable after Fluralaner (Bravecto) in dogs

The FDA has received 407 reports of unpalatable in dogs after Fluralaner. That is 0.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

407Reports

65%Marked serious

62%Recovered

2.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

98 58%

1–2 days

17 10%

3–7 days

4 2.4%

1–4 weeks

10 5.9%

Over a month

40 24%

How the animals did

Recovered

249 61%

Recovered with lasting effects

5 1.2%

Still unwell when reported

128 31%

Died

8 2.0%

Euthanised

1 0.2%

Not known

16 3.9%

Problems reported at the same time

Product defect, general

274 67%

255 63%

246 60%

74 18%

49 12%

34 8.4%

Drug administration error

33 8.1%

Diarrhea

31 7.6%

Age of the animals

Under 1 year

1–3 years

143

4–7 years

124

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause unpalatable in dogs?: 407 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unpalatable with similar medicines

Unpalatable after Afoxolaner (NexGard) 51 reports · 0.1% of its reports
Unpalatable after Sarolaner (Simparica) 21 reports · 0.1% of its reports
Unpalatable after Lotilaner (Credelio) 140 reports · 1.4% of its reports
Unpalatable after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 20 reports · 0.2% of its reports
Unpalatable after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 132 reports · 4.3% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with unpalatable