Excessive thirst after Lotilaner (Credelio) in dogs

The FDA has received 106 reports of excessive thirst in dogs after Lotilaner. That is 1.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines.

106Reports

28%Marked serious

11%Recovered

6.6%Died or euthanised

4 daysTypical onset

How soon it started

Same day

29 33%

1–2 days

14 16%

3–7 days

4 4.5%

1–4 weeks

9 10%

Over a month

32 36%

How the animals did

Recovered

12 11%

Still unwell when reported

59 56%

Died

2 1.9%

Euthanised

5 4.7%

Not known

28 26%

Problems reported at the same time

65 61%

26 25%

24 23%

21 20%

20 19%

18 17%

14 13%

Decreased urine concentration

12 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause excessive thirst in dogs?: 106 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

Excessive thirst after Fluralaner (Bravecto) 634 reports · 0.9% of its reports
Excessive thirst after Afoxolaner (NexGard) 422 reports · 0.7% of its reports
Excessive thirst after Sarolaner (Simparica) 93 reports · 0.6% of its reports
Excessive thirst after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 30 reports · 0.3% of its reports
Excessive thirst after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 22 reports · 0.7% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with excessive thirst