Reddening of the skin after Lokivetmab (Cytopoint) in dogs

The FDA has received 132 reports of reddening of the skin in dogs after Lokivetmab. That is 2.0% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

132Reports
57%Marked serious
16%Recovered
3.0%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
39 38%
1–2 days
10 9.7%
3–7 days
8 7.8%
1–4 weeks
21 20%
Over a month
25 24%

How the animals did

Recovered
21 16%
Still unwell when reported
87 66%
Died
3 2.3%
Euthanised
1 0.8%
Not known
20 15%

Problems reported at the same time

Allergic reaction
44 33%
Itching
41 31%
Didn't work as expected
40 30%
Vomiting
39 30%
Swelling
36 27%
Skin rash or irritation
23 17%
Diarrhea
18 14%
Lethargy
18 14%

Age of the animals

Under 1 year
2
1–3 years
32
4–7 years
53
8–11 years
31
12+ years
11

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause reddening of the skin in dogs?
132 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

All reported side effects of Lokivetmab in dogs · Medicines most reported with reddening of the skin