Neutropenia after Lokivetmab (Cytopoint) in dogs

109 reports to the FDA describe neutropenia in dogs given Lokivetmab. That is 1.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

109Reports

31%Marked serious

5.5%Recovered

7.3%Died or euthanised

90 daysTypical onset

How soon it started

Same day

3 4.0%

1–2 days

8 11%

3–7 days

7 9.3%

1–4 weeks

8 11%

Over a month

49 65%

How the animals did

Recovered

6 5.5%

Still unwell when reported

75 69%

Died

2 1.8%

Euthanised

6 5.5%

Not known

20 18%

Problems reported at the same time

Leucopenia

48 44%

Lymphopenia

36 33%

Liver problems

27 25%

Didn't work as expected

27 25%

25 23%

24 22%

23 21%

20 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause neutropenia in dogs?: 109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 90 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

Neutropenia after Bedinvetmab (Librela) 50 reports · 0.3% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with neutropenia