Elevated cholesterol (total) after Lokivetmab (Cytopoint) in dogs

The FDA has received 42 reports of elevated cholesterol (total) in dogs after Lokivetmab. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

42Reports
52%Marked serious
2.4%Recovered
2.4%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
8 25%
1–2 days
3 9.4%
3–7 days
1 3.1%
1–4 weeks
4 13%
Over a month
16 50%

How the animals did

Recovered
1 2.4%
Still unwell when reported
30 71%
Euthanised
1 2.4%
Not known
10 24%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
13
8–11 years
16
12+ years
13

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause elevated cholesterol (total) in dogs?
42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated cholesterol (total) with similar medicines

All reported side effects of Lokivetmab in dogs · Medicines most reported with elevated cholesterol (total)