Behaviour change after Ketoconazole in dogs

The FDA has received 117 reports of behaviour change in dogs after Ketoconazole. That is 5.2% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

117Reports
62%Marked serious
27%Recovered
9.4%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
22 23%
1–2 days
15 16%
3–7 days
16 17%
1–4 weeks
16 17%
Over a month
25 27%

How the animals did

Recovered
30 26%
Recovered with lasting effects
2 1.7%
Still unwell when reported
47 40%
Died
5 4.3%
Euthanised
6 5.1%
Not known
27 23%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
19
4–7 years
42
8–11 years
27
12+ years
16

About this medicine

Type: medicine.

Questions owners ask

Can Ketoconazole cause behaviour change in dogs?
117 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Ketoconazole in dogs · Medicines most reported with behaviour change