Musculoskeletal disorder after Imidacloprid + Moxidectin (Advantage Multi) in dogs
40 reports to the FDA describe musculoskeletal disorder in dogs given Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.
40Reports
88%Marked serious
38%Recovered
20%Died or euthanised
5 daysTypical onset
Sponsored
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Imidacloprid + Moxidectin cause musculoskeletal disorder in dogs?
- 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 5 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Musculoskeletal disorder with similar medicines
- Musculoskeletal disorder after Spinosad (Comfortis) 93 reports · 0.2% of its reports
- Musculoskeletal disorder after Lufenuron + Milbemycin Oxime (Sentinel) 29 reports · 0.1% of its reports
All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with musculoskeletal disorder