Incorrect route of drug administration after Imidacloprid + Moxidectin (Advantage Multi) in dogs

152 reports to the FDA describe incorrect route of drug administration in dogs given Imidacloprid + Moxidectin. That is 1.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

152Reports
70%Marked serious
40%Recovered
2.0%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
82 69%
1–2 days
34 29%
3–7 days
1 0.8%
1–4 weeks
1 0.8%
Over a month
1 0.8%

How the animals did

Recovered
61 40%
Still unwell when reported
10 6.6%
Died
1 0.7%
Euthanised
2 1.3%
Not known
78 51%

Problems reported at the same time

Age of the animals

Under 1 year
51
1–3 years
34
4–7 years
28
8–11 years
19
12+ years
2

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause incorrect route of drug administration in dogs?
152 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with incorrect route of drug administration