Hair change after Imidacloprid + Moxidectin (Advantage Multi) in dogs

20 reports to the FDA describe hair change in dogs given Imidacloprid + Moxidectin. That is 0.2% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports
50%Marked serious
10%Recovered
5.0%Died or euthanised
–Typical onset
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How the animals did

Recovered
2 10%
Still unwell when reported
1 5.0%
Euthanised
1 5.0%
Not known
16 80%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
6
4–7 years
5
8–11 years
5
12+ years
1

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause hair change in dogs?
20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with hair change