Abnormal posture after Imidacloprid + Moxidectin (Advantage Multi) in dogs

The FDA has received 37 reports of abnormal posture in dogs after Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

37Reports
89%Marked serious
59%Recovered
19%Died or euthanised
1 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
11 35%
1–2 days
10 32%
3–7 days
5 16%
1–4 weeks
4 13%
Over a month
1 3.2%

How the animals did

Recovered
20 54%
Recovered with lasting effects
2 5.4%
Died
4 11%
Euthanised
3 8.1%
Not known
8 22%

Problems reported at the same time

Age of the animals

Under 1 year
6
1–3 years
10
4–7 years
11
8–11 years
4
12+ years
5

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause abnormal posture in dogs?
37 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal posture with similar medicines

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with abnormal posture