Weight gain after Ilunocitinib (Zenrelia) in dogs

The FDA has received 41 reports of weight gain in dogs after Ilunocitinib. That is 1.9% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

41Reports

22%Marked serious

12%Recovered

12%Died or euthanised

121 daysTypical onset

How soon it started

Same day

2 5.6%

1–2 days

0 0.0%

3–7 days

0 0.0%

1–4 weeks

6 17%

Over a month

28 78%

How the animals did

Recovered

5 12%

Still unwell when reported

21 51%

Died

1 2.4%

Euthanised

4 9.8%

Not known

10 24%

Problems reported at the same time

6 15%

6 15%

6 15%

5 12%

5 12%

Decreased haematocrit

5 12%

Behaviour change

5 12%

Death

5 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause weight gain in dogs?: 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 121 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Weight gain with similar medicines

Weight gain after Oclacitinib (Apoquel) 285 reports · 1.0% of its reports
Weight gain after Cyclosporine (Atopica) 93 reports · 0.6% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with weight gain