Intestinal perforation after Hydromorphone in dogs

24 reports to the FDA describe intestinal perforation in dogs given Hydromorphone. That is 2.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

96%Marked serious

21%Recovered

67%Died or euthanised

4 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

4 22%

3–7 days

6 33%

1–4 weeks

7 39%

Over a month

1 5.6%

How the animals did

Recovered

5 21%

Still unwell when reported

2 8.3%

Died

5 21%

Euthanised

11 46%

Not known

1 4.2%

Problems reported at the same time

16 67%

16 67%

15 63%

15 63%

15 63%

Abnormal radiograph finding

13 54%

Vomiting

12 50%

Fluid in abdomen

12 50%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Hydromorphone cause intestinal perforation in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Intestinal perforation with similar medicines

Intestinal perforation after Butorphanol 23 reports · 0.5% of its reports
Intestinal perforation after Cefpodoxime 23 reports · 0.6% of its reports
Intestinal perforation after Tramadol 92 reports · 2.4% of its reports
Intestinal perforation after Propofol 27 reports · 0.9% of its reports
Intestinal perforation after Isoflurane 35 reports · 1.3% of its reports
Intestinal perforation after Cephalexin 28 reports · 1.0% of its reports
Intestinal perforation after Chondroitin + Glucosamine 23 reports · 0.9% of its reports
Intestinal perforation after Ketamine 26 reports · 1.4% of its reports
Intestinal perforation after Midazolam 20 reports · 1.7% of its reports
Intestinal perforation after Ampicillin 23 reports · 2.4% of its reports

All reported side effects of Hydromorphone in dogs · Medicines most reported with intestinal perforation