Intestinal perforation after Butorphanol in dogs

23 reports to the FDA describe intestinal perforation in dogs given Butorphanol. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

91%Marked serious

35%Recovered

48%Died or euthanised

4 daysTypical onset

How soon it started

Same day

2 12%

1–2 days

1 5.9%

3–7 days

10 59%

1–4 weeks

2 12%

Over a month

2 12%

How the animals did

Recovered

8 35%

Still unwell when reported

2 8.7%

Died

8 35%

Euthanised

3 13%

Not known

2 8.7%

Problems reported at the same time

18 78%

17 74%

15 65%

11 48%

9 39%

9 39%

8 35%

8 35%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Butorphanol cause intestinal perforation in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Intestinal perforation with similar medicines

Intestinal perforation after Cefpodoxime 23 reports · 0.6% of its reports
Intestinal perforation after Tramadol 92 reports · 2.4% of its reports
Intestinal perforation after Propofol 27 reports · 0.9% of its reports
Intestinal perforation after Isoflurane 35 reports · 1.3% of its reports
Intestinal perforation after Cephalexin 28 reports · 1.0% of its reports
Intestinal perforation after Chondroitin + Glucosamine 23 reports · 0.9% of its reports
Intestinal perforation after Ketamine 26 reports · 1.4% of its reports
Intestinal perforation after Midazolam 20 reports · 1.7% of its reports
Intestinal perforation after Hydromorphone 24 reports · 2.3% of its reports
Intestinal perforation after Ampicillin 23 reports · 2.4% of its reports

All reported side effects of Butorphanol in dogs · Medicines most reported with intestinal perforation