Urinary tract infection after Fluralaner (Bravecto) in dogs

The FDA has received 216 reports of urinary tract infection in dogs after Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

216Reports

93%Marked serious

13%Recovered

16%Died or euthanised

2 daysTypical onset

How soon it started

Same day

32 26%

1–2 days

32 26%

3–7 days

19 15%

1–4 weeks

10 8.1%

Over a month

31 25%

How the animals did

Recovered

21 9.7%

Recovered with lasting effects

8 3.7%

Still unwell when reported

120 56%

Died

12 5.6%

Euthanised

23 11%

Not known

32 15%

Problems reported at the same time

66 31%

59 27%

53 25%

42 19%

41 19%

Inappropriate urination

36 17%

Death

34 16%

Diarrhea

34 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause urinary tract infection in dogs?: 216 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary tract infection with similar medicines

Urinary tract infection after Afoxolaner (NexGard) 150 reports · 0.3% of its reports
Urinary tract infection after Sarolaner (Simparica) 48 reports · 0.3% of its reports
Urinary tract infection after Lotilaner (Credelio) 43 reports · 0.4% of its reports
Urinary tract infection after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 24 reports · 0.3% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with urinary tract infection