Unresponsive after Fluralaner (Bravecto) in dogs

225 reports to the FDA describe unresponsive in dogs given Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

225Reports
97%Marked serious
25%Recovered
41%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
40 29%
1–2 days
38 28%
3–7 days
16 12%
1–4 weeks
13 9.6%
Over a month
29 21%

How the animals did

Recovered
49 22%
Recovered with lasting effects
7 3.1%
Still unwell when reported
54 24%
Died
45 20%
Euthanised
47 21%
Not known
23 10%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
49
4–7 years
58
8–11 years
63
12+ years
33

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause unresponsive in dogs?
225 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with unresponsive