Shivering after Fluralaner (Bravecto) in dogs

The FDA has received 129 reports of shivering in dogs after Fluralaner. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

129Reports
74%Marked serious
41%Recovered
11%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
27 35%
1–2 days
26 33%
3–7 days
5 6.4%
1–4 weeks
8 10%
Over a month
12 15%

How the animals did

Recovered
51 40%
Recovered with lasting effects
2 1.6%
Still unwell when reported
41 32%
Died
5 3.9%
Euthanised
9 7.0%
Not known
21 16%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
35
4–7 years
33
8–11 years
24
12+ years
22

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause shivering in dogs?
129 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Shivering with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with shivering