Proteinuria after Fluralaner (Bravecto) in dogs

The FDA has received 217 reports of proteinuria in dogs after Fluralaner. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

217Reports

90%Marked serious

6.5%Recovered

29%Died or euthanised

4 daysTypical onset

How soon it started

Same day

25 20%

1–2 days

31 25%

3–7 days

14 11%

1–4 weeks

13 11%

Over a month

40 33%

How the animals did

Recovered

6 2.8%

Recovered with lasting effects

8 3.7%

Still unwell when reported

106 49%

Died

20 9.2%

Euthanised

44 20%

Not known

33 15%

Problems reported at the same time

104 48%

94 43%

91 42%

79 36%

76 35%

64 29%

49 23%

41 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause proteinuria in dogs?: 217 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Afoxolaner (NexGard) 166 reports · 0.3% of its reports
Proteinuria after Sarolaner (Simparica) 45 reports · 0.3% of its reports
Proteinuria after Lotilaner (Credelio) 61 reports · 0.6% of its reports
Proteinuria after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 26 reports · 0.3% of its reports
Proteinuria after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 21 reports · 0.7% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with proteinuria