Localised pain (see other 'socs' for specific pain) after Fluralaner (Bravecto) in dogs

The FDA has received 139 reports of localised pain (see other 'socs' for specific pain) in dogs after Fluralaner. That is 0.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

139Reports

91%Marked serious

15%Recovered

19%Died or euthanised

2 daysTypical onset

How soon it started

Same day

20 23%

1–2 days

29 33%

3–7 days

8 9.1%

1–4 weeks

13 15%

Over a month

18 20%

How the animals did

Recovered

17 12%

Recovered with lasting effects

4 2.9%

Still unwell when reported

65 47%

Died

8 5.8%

Euthanised

19 14%

Not known

26 19%

Problems reported at the same time

66 47%

56 40%

36 26%

35 25%

34 24%

26 19%

26 19%

25 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause localised pain (see other 'socs' for specific pain) in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Localised pain (see other 'socs' for specific pain) with similar medicines

Localised pain (see other 'socs' for specific pain) after Afoxolaner (NexGard) 66 reports · 0.1% of its reports
Localised pain (see other 'socs' for specific pain) after Sarolaner (Simparica) 25 reports · 0.2% of its reports
Localised pain (see other 'socs' for specific pain) after Lotilaner (Credelio) 24 reports · 0.2% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with localised pain (see other 'socs' for specific pain)