Intestinal disorder after Fluralaner (Bravecto) in dogs

125 reports to the FDA describe intestinal disorder in dogs given Fluralaner. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

125Reports
95%Marked serious
15%Recovered
38%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
23 28%
1–2 days
25 30%
3–7 days
13 16%
1–4 weeks
3 3.7%
Over a month
18 22%

How the animals did

Recovered
13 10%
Recovered with lasting effects
6 4.8%
Still unwell when reported
49 39%
Died
18 14%
Euthanised
29 23%
Not known
10 8.0%

Problems reported at the same time

Age of the animals

Under 1 year
10
1–3 years
31
4–7 years
30
8–11 years
37
12+ years
15

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause intestinal disorder in dogs?
125 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Intestinal disorder with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with intestinal disorder