Injection site reaction after Fluralaner (Bravecto) in dogs

150 reports to the FDA describe injection site reaction in dogs given Fluralaner. That is 0.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported less often than average with this medicine.

150Reports

49%Marked serious

16%Recovered

6.0%Died or euthanised

6 daysTypical onset

How soon it started

Same day

32 30%

1–2 days

13 12%

3–7 days

20 19%

1–4 weeks

27 25%

Over a month

16 15%

How the animals did

Recovered

24 16%

Still unwell when reported

104 69%

Died

4 2.7%

Euthanised

5 3.3%

Not known

13 8.7%

Problems reported at the same time

32 21%

30 20%

23 15%

21 14%

13 8.7%

10 6.7%

10 6.7%

9 6.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause injection site reaction in dogs?: 150 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Afoxolaner (NexGard) 165 reports · 0.3% of its reports
Injection site reaction after Sarolaner (Simparica) 22 reports · 0.1% of its reports
Injection site reaction after Lotilaner (Credelio) 67 reports · 0.7% of its reports
Injection site reaction after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 28 reports · 0.9% of its reports

All reported side effects of Fluralaner in dogs · Medicines most reported with injection site reaction