Swelling after Fluralaner (Bravecto) in dogs

The FDA has received 872 reports of swelling in dogs after Fluralaner. That is 1.3% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

872Reports
84%Marked serious
33%Recovered
12%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
382 56%
1–2 days
120 17%
3–7 days
46 6.7%
1–4 weeks
52 7.6%
Over a month
87 13%

How the animals did

Recovered
276 32%
Recovered with lasting effects
13 1.5%
Still unwell when reported
381 44%
Died
40 4.6%
Euthanised
68 7.8%
Not known
94 11%

Problems reported at the same time

Age of the animals

Under 1 year
86
1–3 years
301
4–7 years
249
8–11 years
159
12+ years
56

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause swelling in dogs?
872 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with swelling