General illness after Fluralaner (Bravecto) in dogs

The FDA has received 65 reports of general illness in dogs after Fluralaner. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

65Reports
86%Marked serious
18%Recovered
43%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
12 39%
1–2 days
7 23%
3–7 days
3 9.7%
1–4 weeks
5 16%
Over a month
4 13%

How the animals did

Recovered
11 17%
Recovered with lasting effects
1 1.5%
Still unwell when reported
10 15%
Died
14 22%
Euthanised
14 22%
Not known
15 23%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
7
4–7 years
13
8–11 years
15
12+ years
11

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on).

Products with this ingredient include Bravecto. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner cause general illness in dogs?
65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

General illness with similar medicines

All reported side effects of Fluralaner in dogs · Medicines most reported with general illness