Vocalising after Fluoxetine in dogs

The FDA has received 86 reports of vocalising in dogs after Fluoxetine. That is 3.3% of all reports for this medicine, compared with 1.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

86Reports

37%Marked serious

28%Recovered

9.3%Died or euthanised

15 daysTypical onset

How soon it started

Same day

7 16%

1–2 days

9 21%

3–7 days

3 7.0%

1–4 weeks

6 14%

Over a month

18 42%

How the animals did

Recovered

17 20%

Recovered with lasting effects

7 8.1%

Still unwell when reported

11 13%

Died

2 2.3%

Euthanised

6 7.0%

Not known

43 50%

Problems reported at the same time

Loss of appetite

26 30%

Behaviour change

26 30%

Restlessness or agitation

21 24%

Lethargy

20 23%

Tremors

19 22%

Didn't work as expected

16 19%

Vomiting

15 17%

Breathing problems

14 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause vocalising in dogs?: 86 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Gabapentin 387 reports · 4.3% of its reports
Vocalising after Selegiline (Anipryl) 100 reports · 2.4% of its reports
Vocalising after Trazodone 68 reports · 2.7% of its reports
Vocalising after Clomipramine (Clomicalm) 71 reports · 4.7% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with vocalising