Skin disorders after Fipronil + S-methoprene (Frontline Plus) in dogs
113 reports to the FDA describe skin disorders in dogs given Fipronil + S-methoprene. That is 3.8% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.
113Reports
89%Marked serious
5.3%Recovered
0.0%Died or euthanised
47 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Fipronil kills fleas and ticks (spot-on).
Products with this combination include Frontline Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Questions owners ask
- Can Fipronil + S-methoprene cause skin disorders in dogs?
- 113 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 47 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Skin disorders with similar medicines
- Skin disorders after Spinosad (Comfortis) 124 reports · 0.2% of its reports
- Skin disorders after Lufenuron + Milbemycin Oxime (Sentinel) 36 reports · 0.1% of its reports
- Skin disorders after Imidacloprid + Moxidectin (Advantage Multi) 38 reports · 0.3% of its reports
- Skin disorders after Nitenpyram (Capstar) 38 reports · 0.4% of its reports
All reported side effects of Fipronil + S-methoprene in dogs · Medicines most reported with skin disorders