Behaviour change after Estriol in dogs

The FDA has received 88 reports of behaviour change in dogs after Estriol. That is 4.3% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

88Reports
64%Marked serious
16%Recovered
13%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
6 13%
1–2 days
4 8.7%
3–7 days
4 8.7%
1–4 weeks
18 39%
Over a month
14 30%

How the animals did

Recovered
12 14%
Recovered with lasting effects
2 2.3%
Still unwell when reported
38 43%
Died
2 2.3%
Euthanised
9 10%
Not known
25 28%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
17
4–7 years
23
8–11 years
22
12+ years
20

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause behaviour change in dogs?
88 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Estriol in dogs · Medicines most reported with behaviour change