Hypoproteinaemia after Doxycycline in dogs

The FDA has received 46 reports of hypoproteinaemia in dogs after Doxycycline. That is 1.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports
87%Marked serious
11%Recovered
57%Died or euthanised
35 daysTypical onset
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How soon it started

Same day
4 10%
1–2 days
3 7.7%
3–7 days
6 15%
1–4 weeks
6 15%
Over a month
20 51%

How the animals did

Recovered
4 8.7%
Recovered with lasting effects
1 2.2%
Still unwell when reported
11 24%
Died
6 13%
Euthanised
20 43%
Not known
4 8.7%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
16
4–7 years
15
8–11 years
5
12+ years
7

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause hypoproteinaemia in dogs?
46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 35 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

All reported side effects of Doxycycline in dogs · Medicines most reported with hypoproteinaemia