Hyperproteinaemia after Doxycycline in dogs

32 reports to the FDA describe hyperproteinaemia in dogs given Doxycycline. That is 0.8% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

32Reports

78%Marked serious

0.0%Recovered

41%Died or euthanised

15 daysTypical onset

How soon it started

Same day

3 11%

1–2 days

3 11%

3–7 days

4 14%

1–4 weeks

8 29%

Over a month

10 36%

How the animals did

Still unwell when reported

12 38%

Died

4 13%

Euthanised

9 28%

Not known

7 22%

Problems reported at the same time

23 72%

18 56%

15 47%

15 47%

14 44%

13 41%

13 41%

13 41%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause hyperproteinaemia in dogs?: 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 15 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperproteinaemia with similar medicines

Hyperproteinaemia after Amoxicillin + Clavulanate (Clavamox) 52 reports · 1.0% of its reports
Hyperproteinaemia after Cefovecin (Convenia) 20 reports · 0.5% of its reports
Hyperproteinaemia after Enrofloxacin (Baytril) 27 reports · 0.7% of its reports
Hyperproteinaemia after Metronidazole 22 reports · 0.7% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with hyperproteinaemia