Discoloured urine after Doxycycline in dogs

The FDA has received 24 reports of discoloured urine in dogs after Doxycycline. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

75%Marked serious

8.3%Recovered

29%Died or euthanised

12 daysTypical onset

How soon it started

Same day

5 25%

1–2 days

1 5.0%

3–7 days

1 5.0%

1–4 weeks

9 45%

Over a month

4 20%

How the animals did

Recovered

2 8.3%

Still unwell when reported

13 54%

Died

5 21%

Euthanised

2 8.3%

Not known

2 8.3%

Problems reported at the same time

15 63%

14 58%

12 50%

12 50%

11 46%

7 29%

7 29%

7 29%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Doxycycline treats bacterial and tick-borne infections.

Questions owners ask

Can Doxycycline cause discoloured urine in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Discoloured urine with similar medicines

Discoloured urine after Amoxicillin + Clavulanate (Clavamox) 23 reports · 0.4% of its reports
Discoloured urine after Enrofloxacin (Baytril) 34 reports · 0.9% of its reports
Discoloured urine after Metronidazole 28 reports · 0.9% of its reports

All reported side effects of Doxycycline in dogs · Medicines most reported with discoloured urine