Proteinuria after Dexmedetomidine (Dexdomitor) in dogs

The FDA has received 36 reports of proteinuria in dogs after Dexmedetomidine. That is 0.7% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

36Reports

75%Marked serious

5.6%Recovered

36%Died or euthanised

14 daysTypical onset

How soon it started

Same day

4 13%

1–2 days

5 16%

3–7 days

1 3.2%

1–4 weeks

11 35%

Over a month

10 32%

How the animals did

Recovered

2 5.6%

Still unwell when reported

13 36%

Died

6 17%

Euthanised

7 19%

Not known

8 22%

Problems reported at the same time

24 67%

24 67%

20 56%

18 50%

16 44%

14 39%

13 36%

12 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Products with this ingredient include Dexdomitor, Sileo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Dexmedetomidine cause proteinuria in dogs?: 36 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Buprenorphine 25 reports · 1.6% of its reports

All reported side effects of Dexmedetomidine in dogs · Medicines most reported with proteinuria