Allergic reaction after Dexmedetomidine (Dexdomitor) in dogs

The FDA has received 203 reports of allergic reaction in dogs after Dexmedetomidine. That is 3.7% of all reports for this medicine, compared with 2.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

203Reports

64%Marked serious

37%Recovered

13%Died or euthanised

Same dayTypical onset

How soon it started

Same day

142 82%

1–2 days

12 6.9%

3–7 days

6 3.4%

1–4 weeks

6 3.4%

Over a month

8 4.6%

How the animals did

Recovered

75 37%

Still unwell when reported

71 35%

Died

21 10%

Euthanised

5 2.5%

Not known

31 15%

Problems reported at the same time

82 40%

33 16%

31 15%

29 14%

25 12%

22 11%

22 11%

19 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Products with this ingredient include Dexdomitor, Sileo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Dexmedetomidine cause allergic reaction in dogs?: 203 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Allergic reaction with similar medicines

Allergic reaction after Buprenorphine 95 reports · 6.0% of its reports

All reported side effects of Dexmedetomidine in dogs · Medicines most reported with allergic reaction