Hypernatremia after Desoxycorticosterone Pivalate in dogs

94 reports to the FDA describe hypernatremia in dogs given Desoxycorticosterone Pivalate. That is 2.8% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

94Reports

32%Marked serious

7.4%Recovered

9.6%Died or euthanised

26 daysTypical onset

How soon it started

Same day

3 8.6%

1–2 days

3 8.6%

3–7 days

4 11%

1–4 weeks

10 29%

Over a month

15 43%

How the animals did

Recovered

7 7.4%

Still unwell when reported

11 12%

Died

7 7.4%

Euthanised

2 2.1%

Not known

67 71%

Problems reported at the same time

High sodium-potassium ratio (na:k ratio)

31 33%

28 30%

25 27%

22 23%

19 20%

17 18%

17 18%

14 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Desoxycorticosterone Pivalate cause hypernatremia in dogs?: 94 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 26 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Desoxycorticosterone Pivalate in dogs · Medicines most reported with hypernatremia