Neutropenia after Capromorelin (Entyce) in dogs

The FDA has received 26 reports of neutropenia in dogs after Capromorelin. That is 1.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

81%Marked serious

7.7%Recovered

38%Died or euthanised

16 daysTypical onset

How soon it started

Same day

1 4.0%

1–2 days

7 28%

3–7 days

4 16%

1–4 weeks

2 8.0%

Over a month

11 44%

How the animals did

Recovered

2 7.7%

Still unwell when reported

9 35%

Died

3 12%

Euthanised

7 27%

Not known

5 19%

Problems reported at the same time

17 65%

17 65%

16 62%

15 58%

14 54%

11 42%

11 42%

Leucopenia

10 38%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Capromorelin stimulates appetite.

Products with this ingredient include Entyce, Elura. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Capromorelin cause neutropenia in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

Neutropenia after Maropitant (Cerenia) 188 reports · 1.6% of its reports

All reported side effects of Capromorelin in dogs · Medicines most reported with neutropenia