Eosinopenia after Buprenorphine in dogs

The FDA has received 34 reports of eosinopenia in dogs after Buprenorphine. That is 2.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports

91%Marked serious

5.9%Recovered

50%Died or euthanised

12 daysTypical onset

How soon it started

Same day

7 24%

1–2 days

4 14%

3–7 days

2 6.9%

1–4 weeks

13 45%

Over a month

3 10%

How the animals did

Recovered

1 2.9%

Recovered with lasting effects

1 2.9%

Still unwell when reported

10 29%

Died

5 15%

Euthanised

12 35%

Not known

5 15%

Problems reported at the same time

23 68%

22 65%

21 62%

21 62%

17 50%

15 44%

14 41%

14 41%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause eosinopenia in dogs?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Buprenorphine in dogs · Medicines most reported with eosinopenia