Swelling after Bupivacaine in dogs

The FDA has received 46 reports of swelling in dogs after Bupivacaine. That is 20% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports
48%Marked serious
24%Recovered
8.7%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
18 45%
1–2 days
14 35%
3–7 days
4 10%
1–4 weeks
1 2.5%
Over a month
3 7.5%

How the animals did

Recovered
11 24%
Still unwell when reported
19 41%
Died
1 2.2%
Euthanised
3 6.5%
Not known
12 26%

Problems reported at the same time

Application site reaction
5 11%
Decreased packed cell volume (pcv)
5 11%
Fever
5 11%
4 8.7%
Leucocytosis
4 8.7%

Age of the animals

Under 1 year
4
1–3 years
13
4–7 years
17
8–11 years
6
12+ years
1

About this medicine

Type: medicine.

Questions owners ask

Can Bupivacaine cause swelling in dogs?
46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Bupivacaine in dogs · Medicines most reported with swelling