Application site reaction after Bupivacaine Lipsome in dogs

The FDA has received 28 reports of application site reaction in dogs after Bupivacaine Lipsome. That is 31% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports

75%Marked serious

50%Recovered

0.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

10 38%

1–2 days

13 50%

3–7 days

0 0.0%

1–4 weeks

3 12%

Over a month

0 0.0%

How the animals did

Recovered

14 50%

Not known

14 50%

Problems reported at the same time

Injection site reaction

10 36%

Swelling

6 21%

Seroma

2 7.1%

Loss of appetite

2 7.1%

Skin redness

2 7.1%

Dehiscence

2 7.1%

Hypoproteinaemia

1 3.6%

Pale mucous membrane

1 3.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Bupivacaine Lipsome cause application site reaction in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Application site reaction with similar medicines

Application site reaction after Melarsomine (Immiticide) 22 reports · 0.1% of its reports
Application site reaction after Diphenhydramine 47 reports · 1.0% of its reports
Application site reaction after Butorphanol 28 reports · 0.6% of its reports
Application site reaction after Cefpodoxime 47 reports · 1.2% of its reports
Application site reaction after Tramadol 23 reports · 0.6% of its reports
Application site reaction after Florfenicol + Mometasone + Terbinafine 104 reports · 2.9% of its reports
Application site reaction after Isoflurane 20 reports · 0.7% of its reports
Application site reaction after Cephalexin 21 reports · 0.8% of its reports
Application site reaction after Famotidine 25 reports · 0.9% of its reports
Application site reaction after Clotrimazole + Gentamicin + Mometasone 42 reports · 1.6% of its reports

All reported side effects of Bupivacaine Lipsome in dogs · Medicines most reported with application site reaction