Luxation/subluxation after Bedinvetmab (Librela) in dogs

The FDA has received 69 reports of luxation/subluxation in dogs after Bedinvetmab. That is 0.4% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

69Reports

68%Marked serious

1.4%Recovered

12%Died or euthanised

42 daysTypical onset

How soon it started

Same day

4 7.0%

1–2 days

8 14%

3–7 days

3 5.3%

1–4 weeks

8 14%

Over a month

34 60%

How the animals did

Recovered with lasting effects

1 1.4%

Still unwell when reported

50 72%

Died

1 1.4%

Euthanised

7 10%

Not known

10 14%

Problems reported at the same time

Bone and joint disorder

36 52%

Lameness

28 41%

Abnormal radiograph finding

28 41%

Swelling

21 30%

Arthritis

11 16%

Musculoskeletal disorder

10 14%

Limb non-weight bearing

9 13%

Hyperextension

9 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause luxation/subluxation in dogs?: 69 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 42 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Bedinvetmab in dogs · Medicines most reported with luxation/subluxation