Musculoskeletal disorder after Bedinvetmab (Librela) in dogs

The FDA has received 754 reports of musculoskeletal disorder in dogs after Bedinvetmab. That is 3.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

754Reports
69%Marked serious
7.7%Recovered
33%Died or euthanised
8 daysTypical onset
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How soon it started

Same day
142 22%
1–2 days
103 16%
3–7 days
73 11%
1–4 weeks
132 21%
Over a month
192 30%

How the animals did

Recovered
57 7.6%
Recovered with lasting effects
1 0.1%
Still unwell when reported
319 42%
Died
57 7.6%
Euthanised
191 25%
Not known
129 17%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
2
4–7 years
40
8–11 years
256
12+ years
380

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause musculoskeletal disorder in dogs?
754 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 8 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Musculoskeletal disorder with similar medicines

All reported side effects of Bedinvetmab in dogs · Medicines most reported with musculoskeletal disorder